Pyrotinib Maleate
Pyrotinib Maleate
CAS: 1397922-61-0
Molecular Formula: C36H35ClN6O7
Pyrotinib Maleate - Names and Identifiers
Pyrotinib Maleate - Physico-chemical Properties
| Molecular Formula | C36H35ClN6O7 |
| Molar Mass | 699.161 |
| Solubility | Soluble in DMSO |
| Storage Condition | -20℃ |
| Physical and Chemical Properties | Bioactive Pyrotinib (SHR-1258, BLTN, Pyrroltinib) dimaleate is an effective, selective and irreversible dual tyrosine kinase inhibitor of EGFR and HER2, with corresponding IC50 values of 0.013 μM and 0.038 μM respectively. |
| Use | Pyrotinib maleate is a salt of Pyrotinib. Pyrotinib also known as SHR-1258, is an orally bioavailable, dual kinase inhibitor of the epidermal growth factor receptor (EGFR or HER-1) and the human epidermal growth factor receptor 2 (ErbB2 or HER-2), with potential antineoplastic activity. Upon oral administration, pyrotinib binds to and inhibits both EGFR and HER2, which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumor cells. EGFR and HER2 are receptor tyrosine kinases that are upregulated in various tumor cell types and play major roles in tumor cell proliferation and tumor vascularization. |
| Target | HER2 EGFR |
Pyrotinib Maleate - Reference
| Reference Show more | 1. Li X, et al. Discovery and development of Pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer. Eur J Pharm Sci. 2017 Jan 21. pii: S0928-0987(17)30043-X. |
Pyrotinib Maleate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.43 ml | 7.151 ml | 14.303 ml |
| 5 mM | 0.286 ml | 1.43 ml | 2.861 ml |
| 10 mM | 0.143 ml | 0.715 ml | 1.43 ml |
| 5 mM | 0.029 ml | 0.143 ml | 0.286 ml |
Last Update：2024-01-02 23:10:35
Pyrotinib Maleate - Cell Experiment
Cell lines: A431, SK-BR-3, NCI-N87Concentrations: 6-7 concentrations (not specific)Incubation Time: 72 hMethod:Cells are incubated in a carbon dioxide (5%CO2) incubator until they reached 85% confluency, subsequently, cell culture medium is replaced by fresh one with Pyrotinib (SHR1258) added in a series of concentrations (6 to 7 concentrations). The cells are then put back to the incubator and cultured continuously. After 72 hours, the activity of the test compounds for inhibiting the cell proliferation is determined by a sulforhodamine B (SRB) method.(Only for Reference)
Last Update：2023-08-16 21:32:38
Pyrotinib Maleate - Animal Experiment
Animal Models: 6-7-week-old female BALB/Ca-nude mice with BT-474/SK-OV-3 xenograftsDosages: 2.5-20 mg/kg, 100 mg/kgAdministration: IV, IG(Only for Reference)
Last Update：2023-08-16 21:32:38
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Multiple SpecificationsSpot supply
Product Name: SHR-1258 dimaleate Visit Supplier Webpage Request for quotationCAS: 1397922-61-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: Pyrotinibdimaleate Visit Supplier Webpage Request for quotationCAS: 1397922-61-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
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Product Name: Pyrotinib dimaleate Visit Supplier Webpage Request for quotationCAS: 1397922-61-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: Pyrotinib dimaleate Visit Supplier Webpage Request for quotation
CAS: 1397922-61-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1397922-61-0
Tel: 18301782025
Email: 3008007409@qq.com
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View History
Pyrotinib Maleate
N6-[ 2-[4-(2,4-DICHLORO-PHENYL)-5-IMIDAZOL-1-YL-PYRIMIDIN-2-YLAMINO]-ETHYL]-3-NITRO-PYRIDINE-2,6-DIAMINE
{2-[(4-甲基哌嗪-1-基)甲基]苯基}甲胺
(S)-4-TERT-BUTOXY-2-CYCLOHEXYL-4-OXOBUTANOIC ACID
VINYL TERMINATED POLY(2-VINYL PYRIDINE)
Cadmium chloride
N-(2,6-二甲基苯基)-2-((2-甲氧基乙基)氨基)乙酰胺盐酸盐
N6-[ 2-[4-(2,4-DICHLORO-PHENYL)-5-IMIDAZOL-1-YL-PYRIMIDIN-2-YLAMINO]-ETHYL]-3-NITRO-PYRIDINE-2,6-DIAMINE
{2-[(4-甲基哌嗪-1-基)甲基]苯基}甲胺
(S)-4-TERT-BUTOXY-2-CYCLOHEXYL-4-OXOBUTANOIC ACID
VINYL TERMINATED POLY(2-VINYL PYRIDINE)
Cadmium chloride
N-(2,6-二甲基苯基)-2-((2-甲氧基乙基)氨基)乙酰胺盐酸盐